A highly potent agonist to protease-activated receptor-2 reveals apical activation of the airway epithelium resulting in Ca -regulated ion conductance
نویسندگان
چکیده
Cara L. Sherwood, Michael O. Daines, Theodore J. Price, Josef Vagner, and Scott Boitano Arizona Respiratory Center, University of Arizona, Tucson, Arizona; Department of Pediatrics, Arizona Health Sciences Center, University of Arizona, Tucson, Arizona; Department of Physiology, Arizona Health Sciences Center, University of Arizona, Tucson, Arizona; Department of Pharmacology, Arizona Health Sciences Center, University of Arizona, Tucson, Arizona; and The BIO5 Collaborative Research Institute, University of Arizona, Tucson, Arizona
منابع مشابه
A highly potent agonist to protease-activated receptor-2 reveals apical activation of the airway epithelium resulting in Ca2+-regulated ion conductance.
The airway epithelium provides a barrier that separates inhaled air and its various particulates from the underlying tissues. It provides key physiological functions in both sensing the environment and initiating appropriate innate immune defenses to protect the lung. Protease-activated receptor-2 (PAR2) is expressed both apically and basolaterally throughout the airway epithelium. One conseque...
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The airway epithelium is an important barrier between the environment and subepithelial tissues. The epithelium is also divided into functionally restricted apical and basolateral domains, and this restriction is dependent on the elements of the barrier. The protease-activated receptor-2 (PAR2) receptor is expressed in airway epithelium, and its activation initiates multiple effects including e...
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تاریخ انتشار 2014